If friends disappoint you over and over, that's in large part your own fault. Once someone has shown a tendency to be self-centered, you need to recognize that and take care of yourself; people aren't going to change simply because you want them to.
Declare today "sacred timeoff limits to everyone, unless invited by you. Take care of your personal wants and needs. Say no, graciously but firmly, to others' demands."
If you take care of your body, it'll take care of you.
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