Skepticism is the highest duty and blind faith the one unpardonable sin.
The improver of natural knowledge absolutely refuses to acknowledge authority, as such. For him, skepticism is the highest of duties; blind faith the one unpardonable sin.
We live in a world which is full of misery and ignorance, and the plain duty of each and all of us is to try to make the little corner he can influence somewhat less miserable and somewhat less ignorant than it was before he entered.
[Scientists] have learned to respect nothing but evidence, and to believe that their highest duty lies in submitting to it however it may jar against their inclinations.
It is the first duty of a hypothesis to be intelligible.
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