When things are going well, something will go wrong. / When things just can't get any worse, they will. / Anytime things appear to be going better, you have overlooked something.
The difficulty really is psychological and exists in the perpetual torment that results from your saying to yourself, "But how can it be like that?" which is a reflection of uncontrolled but utterly vain desire to see it in terms of something familiar. ... If you will simply admit that maybe Nature does behave like this, you will find her a delightful, entrancing thing. Do not keep saying to yourself, if you can possible avoid it, "But how can it be like that?" because you will get 'down the drain', into a blind alley from which nobody has escaped. Nobody knows how it can be like that.
The female mind is capable of understanding analytic geometry... The difficulty may just be that we have never yet discovered a way to communicate with the female mind. If it is done in the right way, you may be able to get something out of it.
It is surprising that people do not believe that there is imagination in science. It is a very interesting kind of imagination, unlike that of the artist. The great difficulty is in trying to imagine something that you have never seen, that is consistent in every detail with what has already been seen, and that is different from what has been thought of; furthermore, it must be definite and not a vague proposition. That is indeed difficult.
The problem of creating something new, but which is consistent with everything which has been seen before, is one of extreme difficulty.
If you have any talent, or any occupation that delights you, do it, and do it to the hilt. Don't ask why, or what difficulties you may get into.
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