There is no scientific study more vital to man than the study of his own brain. Our entire view of the universe depends on it.
I think she [Rosalind Franklin] was a good experimentalist but certainly not of the first rank. She was simply not in the same class as Eigen or Bragg or Pauling, nor was she as good as Dorothy Hodgkin. She did not even select DNA to study. It was given to her. Her theoretical crystallography was very average.
My own prejudices are exactly the opposite of the functionalists': "If you want to understand function, study structure".
The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets.
A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.
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