The experimenter who does not know what he is looking for will not understand what he finds.
Science increases our power in proportion as it lowers our pride.
The doubter is a true man of science: he doubts only himself and his interpretations, but he believes in science.
True science teaches us to doubt and, in ignorance, to refrain.
Men who have excessive faith in their theories or ideas are not only ill prepared for making discoveries; they also make very poor observations. Of necessity, they observe with a preconceived idea, and when they devise an experiment, they can see, in its results,only a confirmation of their theory. In this way they distort observation and often neglect very important facts because they do not further their aim.
Art is 'I'; science is 'we'.
When we meet a fact which contradicts a prevailing theory, we must accept the fact and abandon the theory, even when the theory is supported by great names and generally accepted.
When entering on new ground we must not be afraid to express even risky ideas so as to stimulate research in all directions. As Priestley put it, we must not remain inactive through false modesty based on fear of being mistaken.
We must alter theory to adapt it to nature, but not nature to adapt it to theory.
In a word, I consider hospitals only as the entrance to scientific medicine; they are the first field of observation which a physician enters; but the true sanctuary of medical science is a laboratory; only there can he seek explanations of life in the normal and pathological states by means of experimental analysis.
Man can learn nothing unless he proceeds from the known to the unknown.
Put off your imagination, as you put off your overcoat, when you enter the laboratory. Put it on again, as you put on your overcoat, when you leave.
[Those] who have an excessive faith in their theories or in their ideas are not only poorly disposed to make discoveries, but they also make very poor observations.
The joy of discovery is certainly the liveliest that the mind of man can ever feel.
Effects vary with the conditions which bring them to pass, but laws do not vary. Physiological and pathological states are ruled by the same forces; they differ only because of the special conditions under which the vital laws manifest themselves.
Real science exists, then, only from the moment when a phenomenon is accurately defined as to its nature and rigorously determined in relation to its material conditions, that is, when its law is known. Before that, we have only groping and empiricism.
We must never make experiments to confirm our ideas, but simply to control them.
It is impossible to devise an experiment without a preconceived idea; devising an experiment, we said, is putting a question; we never conceive a question without an idea which invites an answer. I consider it, therefore, an absolute principle that experiments must always be devised in view of a preconceived idea, no matter if the idea be not very clear nor very well defined.
In the philosophic sense, observation shows and experiment teaches.
Man does not limit himself to seeing; he thinks and insists on learning the meaning of phenomena whose existence has been revealed to him by observation. So he reasons, compares facts, puts questions to them, and by the answers which he extracts, tests one by another. This sort of control, by means of reasoning and facts, is what constitutes experiment, properly speaking; and it is the only process that we have for teaching ourselves about the nature of things outside us.
Obervation is a passive science, experimentation is an active science.
In the patient who succumbed, the cause of death was evidently something which was not found in the patient who recovered; this something we must determine, and then we can act on the phenomena or recognize and foresee them accurately. But not by statistics shall we succeed in this; never have statistics taught anything, and never can they teach anything about the nature of the phenomenon.
Ardent desire for knowledge, in fact, is the one motive attracting and supporting investigators in their efforts; and just this knowledge, really grasped and yet always flying before them, becomes at once their sole torment and their sole happiness. Those who do not know the torment of the unknown cannot have the joy of discovery which is certainly the liveliest that the mind of man can ever feel.
Proof that a given condition always precedes or accompanies a phenomenon does not warrant concluding with certainty that a given condition is the immediate cause of that phenomenon. It must still be established that when this condition is removed, the phenomen will no longer appear.
It has often been said that, to make discoveries, one must be ignorant. This opinion, mistaken in itself, nevertheless conceals a truth. It means that it is better to know nothing than to keep in mind fixed ideas based on theories whose confirmation we constantly seek, neglecting meanwhile everything that fails to agree with them.
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