To object that the facts about human nature set limits on our ability to change the world and ourselves makes about as much sense as the lament that our lack of wings sets limits on our ability to 'fly' as far as eagles under our own power.
Karl Marx said, “The task is not just to understand the world but to change it.” A variant to keep in mind is that if you want to change the world you’d better try to understand it. That doesn’t mean listening to a talk or reading a book, though that’s helpful sometimes. You learn from participating. You learn from others. You learn from the people you’re trying to organize. We all have to gain the understanding and the experience to formulate and implement ideas.
Humans may be destroying their chances for decent survival. It won't kill everybody, but it would change the world dramatically.
Those who wish to change the world should have the best possible understanding of the world, including what is revealed by the sciences, some of which they might be able to use for their purposes. That's why workers education, including science and mathematics, has commonly been a concern of left intellectuals.
I am not sure just what Marx had in mind when he wrote that "philosophers have hitherto only interpreted the world in various ways; the point is to change it." Did he mean that philosophy could change the world, or that philosophers should turn to the higher priority of changing the world? If the former, then he presumably meant philosophy in a broad sense of the term, including analysis of the social order and ideas about why it should be changed, and how. In that broad sense, philosophy can play a role, indeed an essential role, in changing the world.
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